I think we all welcomed 2021 with open arms as we look to put the worst of 2020 behind us. We have all been through a lot—we have lost family members and friends to COVID-19, we have seen public health officials harassed and maligned, we sheltered-in-place, stayed home, and radically altered our day-to-day schedules, we have witnessed protests over police brutality and racial discrimination, and we have lived through (and still are living through) a presidential transition unlike any other. Despite all the challenges, turmoil, and changes wrought by 2020, the work of state and territorial public health continues. What is on our ASTHO horizon as we greet this new year and the opportunities and challenges it presents? Here are a few things on my mind as I look toward the future.